For patients with high-grade glioma brain tumours, radiotherapy, chemotherapy and surgery remain palliative treatment options, driving research for a cure. Towards this goal, researchers in Australia have combined X-rays, chemotherapy and a radio-sensitizing drug in vitro to more than double tumour cell death compared to a radiation-only control. The combination selectively targets tumour cells and has the potential to reduce side effects in patients (Phys. Med. Biol. 60 7847 http://iopscience.iop.org/article/10.1088/0031-9155/60/20/7847).